2. Vitamin D for the prevention of cancer<\/u><\/h3>\n
A large randomised controlled trial found that supplementation with vitamin D<\/a> did not result in a lower incidence of invasive cancer or cardiovascular events compared to placebo. However, after excluding deaths within two years of randomisation there was a 25% reduction in deaths from cancer; (Manson et al, Jan 2019).<\/p>\n There have been several publications on this subject over the past year. The primary endpoint of most aspirin studies is cardiovascular disease but data on cancer is also being collected. Results published over the last year cast doubt on aspirin\u2019s role in cancer prevention. However, the results should be read considering that previous research found the effect of aspirin on cancer occurred more than 5 years after starting aspirin and not all studies have long term follow-up data. A major research project<\/a> funded by CRUK and led by Queen Mary University is underway to understand the role of aspiring in cancer prevention better. Manuscripts on this topic published over the last year:<\/p>\n The AspECT trial<\/a> published results suggesting that esomeprazole (a proton-pump inhibitor) and aspirin, especially in combination, improved outcomes in patients with Barrett’s oesophagus. (Jankowski et al, Jul 2018)<\/p>\n Research published over the last year suggest elimination of cervical cancer is achievable.<\/p>\n In a randomised controlled trial,\u00a0E-cigarettes<\/a><\/u> were more effective for smoking cessation than nicotine-replacement therapy; (Hajek et al, Feb 2019). Read more on our blog<\/a>.<\/p>\n Results of the NELSON trial were announced at ASCO<\/a> in October 2018. Read more on our blog<\/a>. Community based \u2018Lung Health Check<\/a>\u2019 screening resulted in high rates of early stage lung cancer detection with minimisation of harms. (Crosbie, et al March 2019)<\/p>\n Could this be the future? Researchers found that the average diagnostic performance (for melanoma detection) of 58 dermatologists was inferior to a deep learning<\/a> convolutional neural networks (CNN). (Haenssle et al, Aug 2018)<\/p>\n A systematic analysis of alcohol use in 195 countries found that the risk of all-cause mortality<\/a>, and of cancers specifically, rises with increasing levels of alcohol consumption, and the level of consumption that minimises health loss is zero.\u00a0 (Global Burden of Disease Study 2016 Alcohol Collaborators, Sep 2018).<\/p>\n Sir David Spiegelhalter was not impressed<\/a>! To quote: \u201cBut claiming there is no \u2018safe\u2019 level does not seem an argument for abstention. There is no safe level of driving, but government do not recommend that people avoid driving.\u201d<\/p>\n Although not directly related to cancer prevention, this is a must read for researchers. A study involving<\/a> 29 teams used the same data-set to address the same research questions. Surprisingly the teams produced a wide variety of results, leading author to conclude that significant variation in the results of analyses of complex data may be difficult to avoid. (Silberzahn et al, Aug 2018).\u00a0 Commentary in blogs by Mad in America<\/a> and The Health Care Blog<\/a>.<\/p>\n The views expressed are those of the author. Posting of the blog does not signify that the Cancer Prevention Group endorse those views or opinions.<\/em><\/p>\n Share this page<\/strong><\/p>\n Subscribe to our mailing list to get updates of new posts.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" We are celebrating our first-year anniversary! We hope you have enjoyed our blog thus far. To celebrate we thought we would highlight ten (18 but who’s counting ?) key research publications in cancer screening and prevention over the last year or so. We\u2019ve linked these publications to any mention of them in our (or other)… Read More »10 must read papers from the last year<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":700,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","cybocfi_hide_featured_image":"","footnotes":""},"categories":[24],"tags":[81,90,92,97,124,125,137,142,198,252,259,290,330,470],"class_list":["post-696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-context","tag-alcohol","tag-artificial-intelligence","tag-aspirin","tag-barretts-oesophagus","tag-cancer-prevention","tag-cancer-prevention-blog","tag-cancerseek","tag-cervical-cancer","tag-e-cigs","tag-hpv","tag-hpv-vaccination","tag-key-manuscripts","tag-must-read","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/posts\/696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/comments?post=696"}],"version-history":[{"count":0,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/posts\/696\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/media\/700"}],"wp:attachment":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/media?parent=696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/categories?post=696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/tags?post=696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}3. Aspirin for the primary prevention of cancer<\/u><\/h3>\n
\n
\n
4. Aspirin to improve outcomes for patients with Barret’s oesophagus\u00a0<\/u><\/h3>\n
5. Cervical cancer control<\/u><\/h3>\n
\n
\n
6. Smoking cessation<\/u><\/h3>\n
7. Lung screening<\/u><\/h3>\n
8. Artificial intelligence<\/u><\/h3>\n
9. Alcohol as a risk factor for cancer<\/u><\/h3>\n
10.\u00a0Analytic choices influence research results<\/u><\/h3>\n
![\"\"](\"https:\/\/cancerprevention.qmul.ac.uk\/wp-content\/uploads\/2019\/05\/twitter.png\")
<\/a><\/p>\n