{"id":1266,"date":"2020-04-07T12:31:39","date_gmt":"2020-04-07T12:31:39","guid":{"rendered":"https:\/\/blogs.kcl.ac.uk\/cancerprevention\/?page_id=1266"},"modified":"2020-04-07T12:31:39","modified_gmt":"2020-04-07T12:31:39","slug":"methylation","status":"publish","type":"page","link":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/methylation\/","title":{"rendered":"Methylation"},"content":{"rendered":"<p><strong>DNA methylation<\/strong>\u00a0is a biological process by which\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Methyl_group\">methyl groups<\/a>\u00a0are added to the\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/DNA\">DNA<\/a>\u00a0molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Promoter_(genetics)\">promoter<\/a>, DNA methylation typically acts to repress gene\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Transcription_(genetics)\">transcription<\/a>. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Genomic_imprinting\">genomic imprinting<\/a>,\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/X-chromosome_inactivation\">X-chromosome inactivation<\/a>, repression of\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Transposable_element\">transposable elements<\/a>,\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Aging\">aging<\/a>, and\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Carcinogenesis\">carcinogenesis<\/a><\/p>\n<p>Abnormal methylation, often arising from lifestyle, environment, or other reasons can lead to cells being driven down the \u2018cancer path\u2019. This means methylation patterns provide one of the strongest signals to detect cancers, particularly the types and tissues of origin (TOO) of these cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA methylation\u00a0is a biological process by which\u00a0methyl groups\u00a0are added to the\u00a0DNA\u00a0molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene\u00a0promoter, DNA methylation typically acts to repress gene\u00a0transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including\u00a0genomic&hellip;&nbsp;<a href=\"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/methylation\/\" rel=\"bookmark\">Read More &raquo;<span class=\"screen-reader-text\">Methylation<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-1266","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/pages\/1266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/comments?post=1266"}],"version-history":[{"count":0,"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/pages\/1266\/revisions"}],"wp:attachment":[{"href":"https:\/\/cancerprevention.qmul.ac.uk\/index.php\/wp-json\/wp\/v2\/media?parent=1266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}